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Lysyl hydroxylase
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Lysyl hydroxylase : ウィキペディア英語版
Lysyl hydroxylase

Lysyl hydroxylase (or procollagen-lysine 5-dioxygenase) is an oxygenase enzyme that catalyzes the hydroxylation of lysine to hydroxylysine. This reaction is necessary to the formation and stabilization of collagen. It takes place following protein synthesis (as a post-translational modification). The protein is a membrane-bound homodimeric enzyme that is localized to the cisternae (lumen) of the rough endoplasmic reticulum.
It requires iron and vitamin C as cofactors.
==Pathology==
A deficiency in its cofactor, Vitamin C, is associated with Scurvy.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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